In contrast to interictal findings, an ictal SPECT investigation of the same patient revealed a significant hyper-perfusion of the bilateral basal ganglia, thalamus, brainstem, and deep cortical layers of bilateral fronto-parietal cortices suggesting a functional deafferentation of the cortex from subcortical structures in early myoclonic encephalopathy. These findings were supported by a recent positron emission tomography (PET) study of an infant with an early myoclonic encephalopathy showing a profound hypoperfusion and hypometabolism of the basal ganglia and thalamus as well as cerebral cortex in the interictal period.

Note, the deeper the burst suppression, the more thalamic cells completely ceased firing. In vivo studies of anaesthetized cats, which aimed to identify the potential cellular correlates of burst suppression, showed that during EEG flattening, up to 70% of thalamic cells were completely silent while the remainder showed rhythmic discharges in delta frequencies. There are only a few experimental studies trying to understand mechanisms of BS. This further infers that there may be a common pathway leading to the state of brain inactivation which may indicate a change in the fundamental properties of the brainвЂ™s arousal circuits. While the mechanisms of BS are still poorly understood, different etiologies resulting in BS indicate that the BS pattern represents a low-order dynamic mechanism that persists in the absence of higher-level brain activity. That all these different conditions produce similar brain activity may suggest that there is a unifying pathophysiological mechanism underlying this broad range of inactivated brain states. Burst suppression can occur during different conditions: Early-Onset Epileptic Encephalopathies such as Ohtahara Syndrome and Early Myoclonic Encephalopathy, coma, hypothermia, and general anesthesia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Д¬ompeting interests: The authors have declared that no competing interests exist.Д«urst suppression (BS) is an electroencephalogram (EEG) pattern characterized by the pseudo periodic alternant phases of high voltage activity (burst, 150вЂ“350 ОјV amplitude) and electrical silence (suppression, less than 25 ОјV amplitude), which is considered as a global state of profound brain inactivation. G., Siniatchkin M.4, and EU FP7 project DESIRE вЂњDevelopment & EpilepsyвЂќ, WP2 & WP4, Japaridze N. Interested researchers may submit requests for confidential data to the corresponding author, Natia Japaridze ( Funding provided by D3 and D2 subproject of Sonderforschungsbereich (SFB) 855 of the German Science Society (DFG), Japaridze N., Muthuraman M., Anwar A. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedДata Availability: Due to ethical restrictions data are available upon request. Received: NovemAccepted: MaPublished: April 30, 2015Д¬opyright: В© 2015 Japaridze et al. Ward, University of British Columbia, CANADA PLoS ONE 10(4):ДЄcademic Editor: Lawrence M. (2015) Neuronal Networks during Burst Suppression as Revealed by Source Analysis. Citation: Japaridze N, Muthuraman M, Reinicke C, Moeller F, Anwar AR, Mideksa KG, et al.

Eeg burst suppression